AKADEMİK ÖZGEÇMİŞ

  • Doktora EGE ÜNİVERSİTESİ - SAĞLIK BİLİMLERİ ENSTİTÜSÜ
  • Lisansüstü EGE ÜNİVERSİTESİ - SAĞLIK BİLİMLERİ ENSTİTÜSÜ - BİYOKİMYA
  • Üniversite EGE ÜNİVERSİTESİ - ECZACILIK FAKÜLTESİ
  • YALÇIN AYFER,ARMAGAN GÜLİZ,TURUNÇ SİNEM EZGİ,KONYALIOĞLU SİBEL,KANIT LÜTFİYE,Potential neuroprotective effect of glutamylcysteine ethyl ester on rat brain against kainic acid induced excitotoxicity, Free Radical Research, 2010, 44, 513 521
  • ARMAGAN GÜLİZ,TURUNÇ SİNEM EZGİ,KANIT LÜTFİYE,YALÇIN AYFER,Effect of melatonin co treatment against kainic acid on thiol redox modulator gene expressions in rat hippocampus, Journal of Asian Association of Schools of Pharmacy, 2012, 1, 44 52
  • TURUNÇ SİNEM EZGİ,KARADENİZ HAKAN,ARMAGAN GÜLİZ,ERDEM GÜRSAN KADRİYE ARZUM,YALÇIN AYFER,Electrochemical determination of glutathione in plasma at carbon nanotubes based screen printed electrodes, COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2013, 16, 695 701
  • TURUNÇ SİNEM EZGİ,KANIT LÜTFİYE,YALÇIN AYFER,Effect of glutamylcysteine ethylester on the levels of c fos mRNA expression glutathione and reactive oxygen species formation in kainic acid excitotoxicity, Journal of Pharmacy and Pharmacology, 2010, 62, 1010 1017
  • SEVGİ FERHAN,YURDASİPER AYSU,KAYNARSOY BUKET,TURUNÇ SİNEM EZGİ,GÜNERİ TAMER,YALÇIN AYFER,Studies on Mefenamic Acid Microparticles Formulation In Vitro Release and In Situ Studies in Rats, AAPS PharmSciTech, 2009, 10, 104 112
  • TURUNÇ SİNEM EZGİ,ARMAGAN GÜLİZ,UYANIKGİL YİĞİT,KANIT LÜTFİYE,KOYLU ERSİN OĞUZ,YALÇIN AYFER,Ex vivo protective effects of nicotinamide and 3 aminobenzamide on rat synaptosomes treated with A 1 42, Cell Biochemistry and Function, 2014, 32, 557 564
  • PRİNZ MİCHAELA,PARLAR SÜLÜNAY,BAYRAKTAR GÜLŞAH,ALPTÜZÜN VİLDAN,ERCİYAS ERÇİN,FALLARERO ADYARY,KARLSSON DANİELA,VUORELA PİA,BUREK MALGORZATA,FÖRSTER CAROLA ,TURUNÇ SİNEM EZGİ,ARMAGAN GÜLİZ,YALÇIN AYFER,SCHİLLER CAROLA,LEUNER KRİSTİNA,KRUG MANUEL,SOTRİFFER CHRİSTOPH A,HOLZGRABE ULRİKE,1 4 Substituted 4 1H pyridylene hydrazone type inhibitors of AChE BuChE and amyloid aggregation crossing the blood brain barrier, European Journal of Pharmaceutical Sciences, 2013, 49, 603 613
  • TURUNÇ SİNEM EZGİ,BOJNİK ENGİN,ARMAGAN GÜLİZ,KANIT LÜTFİYE,BENYHE SANDOR,BORSODİ ANNA,YALÇIN AYFER,Kainic acid induced seizure activity alters the mRNA expression and G protein activation of the opioid nociceptin receptors in the rat brain cortex, Epilepsy Research, 2013, 105, 13 19
  • ARMAGAN GÜLİZ,BOJNİK ENGİN,TURUNÇ SİNEM EZGİ,KANIT LÜTFİYE,GÜNDÜZ ÇINAR ÖZGE,BENYHE SANDOR,BORSODİ ANNA,YALÇIN AYFER,Kainic acid induced changes in the opioid nociceptin system and the stress toxicity pathways in the rat hippocampus, Neurochemistry International, 2012, 60, 555 564
  • CUELLARHERRERA MANOLA,VELASCO ANA LUİSA,VELASCO FRANCİSSO,CHAVEZ LAURA,OROZCOSUAREZ SANDRA,ARMAGAN GÜLİZ,TURUNÇ SİNEM EZGİ,BOJNİK ENGİN,YALÇIN AYFER,BENYHE SANDOR,BORSODİ ANNA ,ROCHA LUİSA,ALONSOVANEGAS MARİO,Mu opioid receptor mRNA expression binding and functional coupling to G proteins in human epileptic hippocampus, Hippocampus, 2012, 22, 122 127
  • BOJNİK ENGİN,TURUNÇ SİNEM EZGİ,ARMAGAN GÜLİZ,KANIT LÜTFİYE,BENYHE SANDOR,YALÇIN AYFER,BORSODİ ANNA,Changes in the cannabinoid CB1 receptor expression level and G protein activation in kainic acid induced seizures, Epilepsy Research, 2012, 99, 64 68
  • ARMAGAN GÜLİZ,KARADENİZ HAKAN,ERDEM GÜRSAN KADRİYE ARZUM,TURUNÇ SİNEM EZGİ,ÇALIŞKAN AYFER,KANIT LÜTFİYE,YALÇIN AYFER,The Comparison of Electrochemical Assay and Agarose Gel Electrophoresis for the Determination of DNA Damage Induced by Kainic Acid, Electroanalysis, 2009, 21, 2468 2476
  • TURUNÇ SİNEM EZGİ,UYANIKGİL YİĞİT,KANIT LÜTFİYE,KOYLU ERSİN OĞUZ,YALÇIN AYFER,Nicotinamide treatment reduces the levels of oxidative stress apoptosis and PARP 1 activity in A 1 42 induced rat model of Alzheimer s disease, Free Radical Research, 2014, 48, 146 158
  • AZAK BURCU,YALÇIN AYFER,ÇİZMECİ GİZEM,TURUNÇ SİNEM EZGİ,Effect of gamma glutamyl cysteinyl ethyl ester on apoptotic miRNA expressions in kainic acid induced excitotoxicity model, Acta Physiologica, 2015, 215, 106 106
  • ÇİZMECİ GİZEM,YALÇIN AYFER,AZAK BURCU,TURUNÇ SİNEM EZGİ,Effect of gamma glutamyl cysteinyl ethyl ester on mitochondrial DNA damage in kainic acid induced excitotoxicity model, Acta Physiologica, 2015, 215, 106 106
  • ARMAGAN GÜLİZ,SEVGİLİ ELVİN,TURUNÇ SİNEM EZGİ,KANIT LÜTFİYE,YALÇIN AYFER,Effect of mefenamic acid on some of the base excision repair enzymes against D serine induced neurotoxicity, Turkish Journal of Pharmaceutical Sciences, 2016, 13, 103 114
  • YALÇIN AYFER,SODDU ELENA,TURUNÇ SİNEM EZGİ,UYANIKGİL YİĞİT,KANIT LÜTFİYE,ARMAGAN GÜLİZ,RASSU GIOVANNA,GAVINI ELISABETH,GIUNCHEDI PAOLO,Neuroprotective Effects of Engineered Polymeric Nasal Microspheres Containing Hydroxypropyl cyclodextrin on Amyloid 1 42 Induced Toxicity, Journal of Pharmaceutical Sciences, 2016, 105, 2372 2380
  • KILIÇARSLAN İREM,TURUNÇ SİNEM EZGİ,KANIT LÜTFİYE,YALÇIN AYFER,Effects of nicotinamide treatment on mRNA expression of various enzymes involved in NAD metabolism in A 1 42 induced neurodegeneration, FREE RADICAL BIOLOGY AND MEDICINE, 2016, 96, 51 52
  • SODDU ELENA,TURUNÇ SİNEM EZGİ,UYANIKGİL YİĞİT,KANIT LÜTFİYE,ARMAGAN GÜLİZ,GUİNCHEDİ PAOLO ,GAVİNİ ELİSABETTA,YALÇIN AYFER,Protective effects of hydroxypropyl cyclodextrin microspheres loaded nasal formulations on amyloid peptide 1 42 induced neurodegeneration,5. International SymposiumNutrition, Oxygen Biology and Medicine,05.06.2013 07.06.2013
  • YALÇIN AYFER,TURUNÇ SİNEM EZGİ,ARMAGAN GÜLİZ,KANIT LÜTFİYE,Regulator Effect of Glutamylcysteine Ethyl Ester on The Levels of Antioxidant Cellular Stress Response and Apoptotic Molecules in Kainic Acid Induced Excitoxicity,The British Neuroscience Association's Biennial Meeting,07.04.2013 10.04.2013
  • TURUNÇ SİNEM EZGİ,UYANIKGİL YİĞİT,KANIT LÜTFİYE,KOYLU ERSİN OĞUZ,YALÇIN AYFER,Neuroprotective effects of PARP 1 inhibitors on the model of Alzheimer s Disease induced by A 1 42,Society for Free Radical Research International Biennial Meeting,06.09.2012 09.09.2012
  • ARMAGAN GÜLİZ,KARADENİZ HAKAN,ERDEM GÜRSAN KADRİYE ARZUM,TURUNÇ SİNEM EZGİ,ÇALIŞKAN AYFER,KANIT LÜTFİYE,YALÇIN AYFER,In vitro and in vivo determination of DNA damage induced by kainic acid using electrochemical assay and agarose gel electrophoresis,The International Congress on Bioinformatics and Biomics,18.05.2011 22.05.2011
  • BOJNİK ENGİN,TURUNÇ SİNEM EZGİ,ARMAGAN GÜLİZ,KANIT LÜTFİYE,BENYHE SANDOR,YALÇIN AYFER,BORSODİ ANNA,Changes in the cannabinoid CB1 receptor expression level and G protein activation in the kainic acid model of epilepsy,European Opioid Conference,13.04.2011 15.04.2011
  • TURUNÇ SİNEM EZGİ,ARMAGAN GÜLİZ,KANIT LÜTFİYE,YALÇIN AYFER,Effect of gamma glutamylcysteine ethyl ester on modulation of c fos gene expressions and glutathione levels in kainic acid model of neurodegeneration,Oxidative Stress in Diseases Conference,23.04.2008 25.04.2008
  • TURUNÇ SİNEM EZGİ,KONYALIOĞLU SİBEL,DOST TURHAN,BİRİNCİOĞLU MUSTAFA,YALÇIN AYFER,Protective Effect of Melatonin on the DNA Damage in Aged Rat Brains Treated by Kainic Acid,Meeting of Balkan Clinical Laboratory Federation Congress,04.09.2007 07.09.2007
  • YALÇIN AYFER,ARMAGAN GÜLİZ,TURUNÇ SİNEM EZGİ,KONYALIOĞLU SİBEL,KANIT LÜTFİYE,Modulation of neuroprotective gene expressions and DNA damage by potential antioxidant molecules in animal models of neurodegeneration,"New Approaches and Develeopments in Molecular Mechanisms of Lipid Peroxidation Associated Disorders” Workshop of COST Action B35: LPO,18.05.2007 18.05.2007
  • YURDASİPER AYSU,KAYNARSOY BUKET,SEVGİ FERHAN,TURUNÇ SİNEM EZGİ,YALÇIN AYFER,Effect of mefenemic acid and its microsponge formulations on the rat brain cortex DNA,13. International Pharmaceutical Technology Symposium,10.09.2006 13.09.2006
  • TURUNÇ SİNEM EZGİ,ARMAGAN GÜLİZ,BOJNİK ENGİN,KANIT LÜTFİYE,BORSODİ ANNA,YALÇIN AYFER,Expressional mRNA levels and G protein activation of opioid system receptors in kainic acid induced neurodegeneration,International Postgraduate Student Meeting on Pharmaceutical Sciences,24.06.2010 27.06.2010
  • TURUNÇ SİNEM EZGİ,ARMAGAN GÜLİZ,YALÇIN AYFER,Effect of raloxifene treatment on thioredoxin and thioredoxin reductase expressions in the rat brain cortex,Molecular and Cell Biology at Spetsai: Past, Present and Future. A Forty Years Anniversary,01.09.2006 05.09.2006
  • ARMAGAN GÜLİZ,TURUNÇ SİNEM EZGİ,YALÇIN AYFER,Effect of raloxifene treatment on the level of APE Ref 1 mRNA expression in brain cortex of ovariectomized female rats,8. International Symposium on Pharmaceutical Sciences,13.06.2006 16.06.2006
  • TURUNÇ SİNEM EZGİ,ARMAGAN GÜLİZ,YALÇIN AYFER,Effect of melatonin on kainic acid induced DNA damage in the rat brain cortex,8. International Symposium on Pharmaceutical Sciences,13.06.2006 16.06.2006
  • ARMAGAN GÜLİZ,TURUNÇ SİNEM EZGİ,YALÇIN AYFER,Quantification of heme oxygenase 1 mRNA expression in the rat brain cortex by reverse transcription PCR following treatment of kainic acid and a selective estrogen receptor modulator substance,FEBS-IUBMB Satellite Meeting: Protein Folding and Transport in Health and Disease,29.06.2005 02.07.2005
  • TURUNÇ SİNEM EZGİ,UYANIKGİL YİĞİT,KANIT LÜTFİYE,KOYLU ERSİN OĞUZ,YALÇIN AYFER,Nikotinamidin A 1 42 ile oluşturulan in vitro nörodejenerasyonda koruyucu etkileri,25. Ulusal Biyokimya Kongresi,03.09.2013 06.09.2013, TÜRKİYE
  • ARMAGAN GÜLİZ,TURUNÇ SİNEM EZGİ,KANIT LÜTFİYE,YALÇIN AYFER,D serine karşı mefenamik asitin baz eksizyon tamir enzimleri ve PARP 1 üzerine etkisi,25. Ulusal Biyokimya Kongresi,03.09.2013 06.09.2013, TÜRKİYE
  • KARADENİZ HAKAN,ARMAGAN GÜLİZ,ERDEM GÜRSAN KADRİYE ARZUM,TURUNÇ SİNEM EZGİ,ÇALIŞKAN AYFER,KANIT LÜTFİYE,YALÇIN AYFER,Kainik asit ile oluşan DNA hasarının elektrokimyasal yöntem ve agaroz jel elektroforezi ile tayini,1. Ege AR-GE ve Teknoloji Günleri,01.12.2010 03.12.2010, TÜRKİYE
  • ARMAGAN GÜLİZ,TURUNÇ SİNEM EZGİ,KANIT LÜTFİYE,YALÇIN AYFER,Alteration on mRNA level of p53 and caspase 3 activity in rat brains treated by gamma glutamylcysteine ethyl ester against kanic acid,Oxidative Stress in Diseases Conference,23.04.2008 25.04.2008
  • YURDASİPER AYSU,KAYNARSOY BUKET,SEVGİ FERHAN,TURUNÇ SİNEM EZGİ,YALÇIN AYFER,The comparative effects of mefenemic acid microsponge formulations with different polymers on the rat brain cortex DNA,3. Pharmaceutical Sciences World Congress,22.04.2007 25.04.2007
  • ARMAGAN GÜLİZ,TURUNÇ SİNEM EZGİ,KANIT LÜTFİYE,YALÇIN AYFER,Modulation of p53 gene expression and caspase 3 activity by gamma glutamylcysteine ethyl ester in kainic acid model of neurodegeneration,Society for Free Radical Research Europe Meeting,10.10.2007 13.10.2007
  • TURUNÇ SİNEM EZGİ,ARMAGAN GÜLİZ,KANIT LÜTFİYE,YALÇIN AYFER,Modulation of c fos gene expressions and glutathione levels by gamma glutamylcysteine ethyl ester in kainic acid model of neurodegeneration,Society for Free Radical Research Europe Meeting,10.10.2007 13.10.2007
  • YALÇIN AYFER,ARMAGAN GÜLİZ,TURUNÇ SİNEM EZGİ,KANIT LÜTFİYE,Elevation of hippocampal glutathione and induction of thiol redox modulator gene expressions by glutamylcysteine ethyl ester against kainic acid induced oxidative stress,Third Biennial Meeting of the Society for Free Radical Research-Asia (SFRR-Asia) & Sixth Annual Meeting of SFRR-India,08.01.2007 11.01.2007
  • ARMAGAN GÜLİZ,TURUNÇ SİNEM EZGİ,YALÇIN AYFER,JANSEN EUGENE,Effect of multivitamin minerals supplemeantation on glutathione peroxidase 1 glutathione reductase and glutathione synthetase gene expression in mice,3. International Conference on Cellular Environmental Stressors in Biology and Medicine: Focus on Redox Reactions,25.06.2014 27.06.2014
  • TURUNÇ SİNEM EZGİ,UYANIKGİL YİĞİT,KANIT LÜTFİYE,KOYLU ERSİN OĞUZ,YALÇIN AYFER,Effect of PARP 1 inhibitors on oxidative stress parameters in A 1 42 induced Alzheimer s Disease model,Society for Free Radical Research Europe Meeting,07.09.2011 10.09.2011
  • DUMAN MERT,ÇELİK CENK,TURUNÇ SİNEM EZGİ,ARMAGAN GÜLİZ,YALÇIN AYFER,ŞENDEMİR ÜRKMEZ AYLİN,An in vitro investigation of long term degenerative effects of mechanical trauma on central nervous system neurons,21. Congress of The European Society of Biomechanics,05.07.2015 08.07.2015, 05.07.2015
  • TURUNÇ SİNEM EZGİ,ARMAGAN GÜLİZ,YALÇIN AYFER,PI3K Akt FoxO signaling mediated neuroprotective effects of nicotinamide in A 1 42 induced experimental Alzheimer Disease s model,Oxygen Club of California World Congress 2015: Oxidants and Antioxidants in Biology,24.06.2015 26.06.2015, 24.06.2015
  • AZAK BURCU,YALÇIN AYFER,ÇİZMECİ GİZEM,TURUNÇ SİNEM EZGİ,Eksitotoksisite modelinde glutamil sisteinil etil ester in spesifik miRNA ekspresyonlarına etkisi,13. Ulusal Sinirbilim Kongresi,30.04.2015 03.05.2015, TÜRKİYE, 30.04.2015
  • ÇİZMECİ GİZEM,YALÇIN AYFER,AZAK BURCU,TURUNÇ SİNEM EZGİ,Eksitotoksisite modelinde glutamil sisteinil etil ester in mitokondriyal DNA hasarına etkisi,13. Ulusal Sinirbilim Kongresi,30.04.2015 03.05.2015, TÜRKİYE, 30.04.2015
  • TURUNÇ SİNEM EZGİ,UYANIKGİL YİĞİT,KANIT LÜTFİYE,KOYLU ERSİN OĞUZ,YALÇIN AYFER,Neuroprotective effects of nicotinamide against A 1 42 induced in vivo and in vitro neurodegeneration models,The British Neuroscience Association's Biennial Meeting,12.04.2015 15.04.2015, 12.04.2015
  • TURUNÇ SİNEM EZGİ,UYANIKGİL YİĞİT,KANIT LÜTFİYE,YALÇIN AYFER,Neuroprotective effects of nicotinamide on apoptotic mechanisms in A 1 42 induced in vivo neurodegeneration,11. International Symposium on Pharmaceutical Sciences,09.06.2015 12.06.2015, 09.06.2015
  • KILIÇARSLAN İREM,TURUNÇ SİNEM EZGİ,KANIT LÜTFİYE,YALÇIN AYFER,Effects of nicotinamide treatment on mRNA expression of various enzymes involved in NAD metabolism in A 1 42 induced neurodegeneration,Society for Free Radical Research Europe Meeting,08.06.2016 11.06.2016
  • TURUNÇ SİNEM EZGİ,YALÇIN AYFER,PARP-1 Enzimini Hedefleyen Terapötik Yaklaşımlar,IVEK 3rd International Convention of Pharmaceticals and Pharmacies,26.04.2017 29.04.2017, 17.05.2017
  • TURUNÇ SİNEM EZGİ,Alzheimer Hastalığında Genetik Alt Yapının ve Çevresel Faktörlerin Etkisi,IVEK 3rd International Convention of Pharmaceuticals and Pharmacies,26.04.2017 29.04.2017, 17.05.2017
  • Kainik asit aracılı eksitotoksisitede hücresel redoks düzeyleri ve c fos mRNA ekspresyonu, Araştırmacı, BAP, Araştırmacı, (1500)
  • Amiloid peptid 1 42 ile oluşturulan in vivo ve in vitro nörodejenerasyon deney modellerinde PARP 1 inhibitörlerinin nöroterapötik etkilerinin araştırılması, Araştırmacı, BAP, Araştırmacı, (9500)
  • D serinle indüklenen nörodejenerasyon modelinde mefenamik asitin DNA hasarı ve tamir mekanizmaları üzerine etkisi, Araştırmacı, BAP, Araştırmacı, (5500)
  • Amiloid peptid 1 42 ile oluşturulan deneysel Alzheimer modelinde nikotinamidin nöroprotektif etkinliğinin fosfatidilinositol 3 kinaz protein kinaz B yolağı üzerinden araştırılması, Yürütücü, BAP, Yürütücü, (4500),15.4.2015
  • Amiloid 1 42 peptidle oluşturulan Alzheimer hastalığı deney modelinde 2 hidroksipropil siklodekstrin HP CD uygulamasının potansiyel nöroprotektif etkileri, Araştırmacı, BAP, Araştırmacı, (4500),6.12.2016
  • Yeni selektif TYK2 enzim inhibitörü olarak tasarlanan triazolopirimidin halkası taşıyan küçük moleküllerin sentezi biyolojik aktiviteleri ve moleküler modelleme çalışmaları, Araştırmacı, TÜBİTAK Destekli Proje, Araştırmacı, (29976)
  • Yeni selektif TYK2 enzim inhibitörü olarak tasarlanan triazolopirimidin halkası taşıyan küçük moleküllerin sentezi ve biyolojik aktiviteleri, Araştırmacı, BAP, Araştırmacı, (10000),29.12.2016
  • Antioksidan etkin madde yüklü nanojel formülasyonların hazırlanması karakterizasyonu ve etkinliğinin değerlendirilmesi, Araştırmacı, BAP, Araştırmacı, (5000)
  • A 1 42 ile Oluşturulan Nörodejenerasyonda Nikotinamid Uygulamasının NAD Metabolizmasında Rol Oynayan Bazı Enzimlerin mRNA Ekspresyonları Üzerine Etkisi, Araştırmacı, BAP, Araştırmacı, (6000),6.12.2016
  • Potansiyel Beta-Amiloid Peptit İnhibitörü Bifenil Konjuge Sistemler Üzerinde Biyolojik Aktivite Çalışmaları, Danışman, TÜBİTAK Destekli Proje, Danışman
  • Koroner Kronik Total Oklüzyonda Transkardiyak Mekanomir Gradiyenti IleKollateral Gelişimi Arasındaki Ilişkinin Belirlenmes, Araştırmacı, TÜBİTAK Destekli Proje, Araştırmacı
  • Demir Oksit (Fe3o4) Nanopartikül Ve Grafen Katkılı Kendiliginden DizilenPeptid Doku Mühendisligi Ürünlerinin In Vitro Ve In Vivo Parkinson Hastalıgı Modellerinde NörorejeneratifEtkisinin Incelenmesi, Araştırmacı, TÜBİTAK Destekli Proje, Araştırmacı
  • Clinical and Experimental Pharmacology and Physiology
  • Journal of Innovations in Applied pharmaceutical Science, Editör,
  • Rel Assay Diagnostics Poster Ödülü,2016
  • Toplantı Katılım Desteği,2006
  • Toplantı Katılım Desteği,2008
  • Poster Ödülü,2011
  • Yurt İçi Doktora Bursu,2007
  • Proje Ödülü,2010

ÇALIŞMA ALANLARI

  • Sağlık Bilimleri Temel Alanı
  • Biyokimya
  • Klinik Biyokimya

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